The Temporal Pattern, Flux, and Function of Autophagy in Spinal Cord Injury

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The Temporal Pattern, Flux, and Function of Autophagy in Spinal Cord Injury

Previous studies have indicated that autophagy plays a critical role in spinal cord injury (SCI), including traumatic spinal cord injury (TSCI) and ischemia-reperfusion spinal cord injury (IRSCI). However, while the understanding of mechanisms underlying autophagy in SCI has progressed, there remain several controversial points: (1) temporal pattern results of autophagic activation after SCI ar...

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Autophagy in Spinal Cord Injury

Introduction: Autophagy is a bulk degradation of subcellular constituents, and is activated in several neurodegenerative conditions [1]. Under stress conditions, the autophagic process can lead to non-apoptotic programmed cell death (type II programmed cell death) [2]. Beclin 1, a Bcl2 interacting protein, is known as a promoter of autophagy [3]. Previous research demonstrated that the expressi...

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Polyphenols have been shown to have some of the neuroprotective effects against neurodegenerative diseases. These effects are attributed to a variety of biological activities, including free radical scavenging/antioxidant and anti-inflammatory and anti-apoptotic activities. In this regard, many efforts have been made to study the effects of various well-known dietary polyphenols on spinal cord ...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2017

ISSN: 1422-0067

DOI: 10.3390/ijms18020466